منابع مشابه
Nitrated lipids: a class of cell-signaling molecules.
I t is becoming increasingly evident that the inflammatory oxidants reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive halogen species (RHS) mediate diverse pathologic processes in cardiovascular, pulmonary, and neurodegenerative diseases (1, 2). RNS (peroxynitrite, nitrogen-dioxide radical, or nitronium ion) are formed from the rapid reaction between ROS (superoxide) ...
متن کاملActivation of the AMP-Activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells
The AMP-activated protein kinase (AMPK) is an important regulator of endothelial metabolic and functional homeostasis. Here, we examined the regulation of AMPK by nitrated oleic acid (OA-NO(2)) and investigated the implications in endothelial function. Treatment of bovine aortic endothelial cells (BAECs) with OA-NO(2) induced a significant increase in both AMPK-Thr172 phosphorylation and AMPK a...
متن کاملQuantification of nitrotyrosine in nitrated proteins
For kinetic studies of protein nitration reactions, we have developed a method for the quantification of nitrotyrosine residues in protein molecules by liquid chromatography coupled to a diode array detector of ultraviolet-visible absorption. Nitrated bovine serum albumin (BSA) and nitrated ovalbumin (OVA) were synthesized and used as standards for the determination of the protein nitration deg...
متن کاملNitrated biomass of stalks Bengal gram
Investigation of uptake capacity of by nitrated biomass of Cicer arientinum(Bngal gram) is conducted in batch conditions. The effect of different parameters such as contact time, sorbent dose, pH and temperature has been studied. Adsorption kinetic modeling data were found out. The kinetics of biosorption results shows that sorption process is well explained by pseudo–second order model with de...
متن کاملProteomic method identifies proteins nitrated in vivo during inflammatory challenge.
Inflammation in asthma, sepsis, transplant rejection, and many neurodegenerative diseases associates an up-regulation of NO synthesis with increased protein nitration at tyrosine. Nitration can cause protein dysfunction and is implicated in pathogenesis, but few proteins that appear nitrated in vivo have been identified. To understand how this modification impacts physiology and disease, we use...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000033471.67751.85